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Kawasaki disease

fever kawasaki

Kawasaki disease (KD) is an illness that affects young children, typically below the age of 5 years old. It is a condition that results in inflammation in the coronary arteries, which are blood vessels that supply blood to the heart.

The cause of Kawasaki disease is not fully understood, although it might result from one’s immune system overreacting to an infection and turning against one’s body as it attacks the coronary arteries. Genetics play a role in this condition, with Asians being more predisposed to getting Kawasaki disease, while it occurs less commonly in Caucasians. Kawasaki disease is not contagious and will not be passed onto someone else.

How can I tell if my child has Kawasaki disease?

Children with Kawasaki disease will have a fever for 5 days or more, and may have several or all the following symptoms:

  • Red eyes, without any discharge
  • Swollen lymph nodes in the neck
  • Changes in the mouth: Red and/or cracked lips; red “strawberry” tongue
  • Changes in the hands and feet: red palms and soles, swelling of the hands and feet, peeling of skin of the fingers and toes (usually 2-3 weeks later)
  • Rash on the body, including the buttock/diaper area
  • Irritability and crankiness
  • Redness of the BCG scar, if your child received a BCG vaccination before.

Doctors diagnose Kawasaki disease based on the symptoms and signs above, usually in the presence of fever and four of the other signs. As the signs may not all appear at the same time, it will be helpful for parents to inform the doctor if their child had any of these symptoms. Children will usually need a number of tests to determine if the condition is affecting other parts of the body, including the heart.

symptoms of kawasaki disease

How are children with Kawasaki disease normally treated?

  • Intravenous Immunoglobulin (IVIg) – this is an infusion of antibodies given through the vein through a drip in the hospital. Your child will feel better the next day. Some children need a second dose.
  • Aspirin – initially at a higher dose, then at a lower dose when fever has settled. This reduces the chance of blood clots developing.
  • Steroids may be needed at times.

What are potential complications of Kawasaki disease?

If untreated, between 20-40% (approximately one-fifth) of children with Kawasaki disease will develop coronary artery aneurysms, which are the weakening and bulging of the vessel wall.  Aneurysms can lead to a heart attack or cause life-threatening internal bleeding.

With treatment however, the risk of developing an aneurysm is reduced significantly to 3-4%. Early treatment can also prevent complications associated with Kawasaki disease.

What happens next?

Children who do not have heart problems usually recover fully. For children whose hearts have been affected by the disease, the outlook varies depending on the degree of damage sustained.

It is uncommon to have a second attack of Kawasaki disease.

dr ooi pei ling paediatrician

Dr Ooi Pei Ling
Paediatric (Rheumatology)
SBCC Baby & Child Clinic

Our Specialist
Dr Ooi Pei Ling is a paediatrician who treats children with general paediatric conditions and sub-specialises in Paediatric Rheumatology.

As part of rheumatology practice, she treats children with autoimmune diseases, musculoskeletal inflammation, vasculitis, periodic fevers and chronic pain syndromes.

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